SERPINB2, an Early Responsive Gene to Epigallocatechin Gallate, Inhibits Migration and Promotes Apoptosis in Esophageal Cancer Cells
Zikai Chen, Yifu Wei, Yuzhong Zheng, Hui Zhu, Qian Teng, Xianglan Lin, Fengnian Wu, Fei Zhou
Journal：Cells
IF：7.67
DOI：10.3390/cells11233852
PMID：36497110
Published：2022-11-30
research field：肿瘤学分子生物学药理学
Abstract
Esophageal cancer is a lethal disease that frequently occurs in developing countries, the incidence of which could be declined by drinking EGCG-enriched drinks or food.SERPINB2, whose complex functions and regulations are not yet fully understood, are induced by multiple inflammatory molecules and anti-tumor agents. Here, we identify 2444 EGCG-regulated genes in esophageal cancer cells, includingSERPINB2. EGCG treatment recruits NF-κB at the promoter and enhancers ofSERPINB2and activates gene transcription, which is repressed by NF-κB knockdown or inhibition. Loss ofSERPINB2leads to a faster migration rate and less expression of Caspase-3 in cancer cells. Our study demonstrates thatSERPINB2is a new tumor-suppressor gene involved in cell movement and apoptosis and could be a therapeutic target for esophageal cancer.Keywords:esophageal cancer;EGCG;SERPINB2;apoptosis
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