Graphdiyne-modified TiO2 nanofibers with osteoinductive and enhanced photocatalytic antibacterial activities to prevent implant infection
Wang Rui, Shi Miusi, Xu Feiyan, Qiu Yun, Zhang Peng, Shen Kailun, Zhao Qin, Yu Jiaguo, Zhang Yufeng
Journal：Nature Communications
IF：12.12
DOI：10.1038/s41467-020-18267-1
PMID：32901012
Published：2020-09-08
research field：生物医学工程材料科学组织工程
Abstract
Titanium implants have been widely used in bone tissue engineering for decades. However, orthopedic implant-associated infections increase the risk of implant failure and even lead to amputation in severe cases. Although TiO 2 has photocatalytic activity to produce reactive oxygen species (ROS), the recombination of generated electrons and holes limits its antibacterial ability. Here, we describe a graphdiyne (GDY) composite TiO 2 nanofiber that combats implant infections through enhanced photocatalysis and prolonged antibacterial ability. In addition, GDY-modified TiO 2 nanofibers exert superior biocompatibility and osteoinductive abilities for cell adhesion and differentiation, thus contributing to the bone tissue regeneration process in drug-resistant bacteria-induced implant infection.
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