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Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion. Membrane clustering requires GTPase activity. It may involve a major rearrangement of the coiled coil domains. Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events. Overexpression induces the formation of mitochondrial networks (in vitro). Has low GTPase activity.

Western

Western blot analysis of Mitofusin 1 in lysates of HepG2,PC-3,PC-12 and EL4.IL-12 using Mitofusin 1 antibody.

Immunohistochemistry

Immunohistochemistry analysis of paraffin-embedded Mouse kidney using Mitofusin 1 antibody.High pressure and temperature Tris/EDTA (PH 9.0) used for antigen retrieval.The brown color represents the positive signal observed with Mitofusin 1 antibody.

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