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The polycomb group (PcG) of proteins contributes to the maintenance of cell identity, stem cell self-renewal, cell cycle regulation, and oncogenesis by maintaining the silenced state of genes that promote cell lineage specification, cell death, and cell-cycle arrest. PcG proteins exist in two complexes that cooperate to maintain long-term gene silencing through epigenetic chromatin modifications. The first complex, EED-EZH2, is recruited to genes by DNA-binding transcription factors and methylates histone H3 on Lys27.

推荐稀释比 WB: 1/500-1/1000  IF: 1/50-1/200  IP: 1/20

Immunocytochemistry

Immunocytochemistry analysis of BMI1 (green) in Hela using BMI1 antibody,and DAPI(blue).

Western

Western blot analysis of Bmi1 in 3T3 lysates using Bmi1 antibody.

Western

Western blot analysis of Bmi1 in C6, rat Brain, Ramos lysates using Bmi1 antibody

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