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Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8.

推荐稀释比 WB:1/500-1/1000;IHC:1/50-1/100

Western blot analysis of LXR alpha in Jurkat lysates using LXR alpha antibody.

Western blot analysis of LXR alpha in rat Brain lysates using LXR alpha antibody.

Immunohistochemistry analysis of paraffin-embedded Human breast cancer using LXR alpha antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

-25 ~ -15℃保存，收到货之后有效期1年，避免反复冻融。