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ABCG2 confers resistance for a variety of chemotherapeutic agents, including anthracyclines, mitoxantrone, bisantrene and topotecan. Play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123.

推荐稀释比 WB:1/500-1/1000

Western blot analysis of BCRP/ABCG2 in HepG2, U251, HL-60 lysates using ABCG2 antibody.

-25 ~ -15℃保存，收到货之后有效期1年，避免反复冻融。