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Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1.

推荐稀释比 WB:1/500-1/1000;IHC:1/50-1/100;IP:1/20

Western blot analysis of Integrin alpha 5 in K562, 3T3 lysates using Integrin alpha 5 antibody.

Immunohistochemistry analysis of paraffin-embedded Human breast cancer using Integrin alpha 5 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

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