The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
推荐稀释比 IHC:1/50-1/100
Immunohistochemistry analysis of paraffin-embedded Human lymphoma tissue using PARN antibbody. High-pressure and temperature Sodium Citrate pH 9.0 was used for antigen retrieval.
Immunohistochemistry analysis of paraffin-embedded Human lung tissue using PARN antibbody. High-pressure and temperature Sodium Citrate pH 9.0 was used for antigen retrieval.
-25 ~ -15℃保存，收到货之后有效期1年，避免反复冻融。
