磷酸英菲格拉替尼(Infigratinib phosphate,又称BGJ-398phosphate、NVP-BGJ398 phosphate)是英菲格拉替尼(infigratinib)的磷酸盐形式,英菲格拉替尼是口服生物可利用的泛成纤维细胞生长因子受体(FGFR)抑制剂。其对FGFR1、FGFR2、FGFR3的半数抑制浓度(IC50)分别为0.9nM、1.4nM、1nM,对FGFR4的IC50为60nM,对FGFR4和血管内皮生长因子受体2(VEGFR2)的抑制活性比FGFR1-3低40倍,对Abl、Fyn、Kit、Lck、Lyn几乎无抑制活性,同时具有潜在的抗血管生成和抗肿瘤活性。
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