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BRD5648是BRD0705的阴性对照化合物。BRD0705是一种高效、具旁系选择性的口服活性GSK3α抑制剂，其IC₅₀为66 nM，Kd为4.8 μM。相较于GSK3β(IC₅₀为515 nM)，BRD0705对GSK3α的选择性约高8倍，适用于急性髓系白血病的研究。

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