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Gardenin A是口服有效的合成PMF类似物，具有神经营养作用（促进神经突生长、神经元分化），还具备镇静、抗焦虑、抗抑郁及抗惊厥活性，其神经营养作用通过激活PC12细胞中MAPK/ERK、PKC、PKA信号通路实现，不激活TrkA、CREB通路。

[1] Chiu SP, Wu MJ, Chen PY, Ho YR, Tai MH, Ho CT, Yen JH. Neurotrophic action of 5-hydroxylated polymethoxyflavones: 5-demethylnobiletin and gardenin A stimulate neuritogenesis in PC12 cells. J Agric Food Chem. 2013 Oct 2;61(39):9453-63. doi: 10.1021/jf4024678. Epub 2013 Sep 23. PMID: 24003765.[2]Alonso-Castro AJ, Gasca-Martínez D, Cortez-Mendoza LV, Alba-Betancourt C, Ruiz-Padilla AJ, Zapata-Morales JR. Evaluation of the neuropharmacological effects of Gardenin A in mice. Drug Dev Res. 2020 Aug;81(5):600-608. doi: 10.1002/ddr.21659. Epub 2020 Mar 17. PMID: 32181517.