A2ti-1是一种高选择性膜联蛋白A2/S100A10异四聚体(A2t)抑制剂,它通过特异性破坏A2与S100A10之间的蛋白相互作用,从而有效抑制人乳头瘤病毒16型(HPV16)的感染。
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-25~-15℃避光保存,有效期3年。
[1] Reddy TR, Li C, Fischer PM, Dekker LV. Three-dimensional pharmacophore design and biochemical screening identifies substituted 1,2,4-triazoles as inhibitors of the annexin A2-S100A10 protein interaction. ChemMedChem. 2012 Aug;7(8):1435-46. doi: 10.1002/cmdc.201200107. Epub 2012 May 29. PMID: 22644793; PMCID: PMC3505905.
[2]Woodham AW, Taylor JR, Jimenez AI, Skeate JG, Schmidt T, Brand HE, Da Silva DM, Kast WM. Small molecule inhibitors of the annexin A2 heterotetramer prevent human papillomavirus type 16 infection. J Antimicrob Chemother. 2015;70(6):1686-90. doi: 10.1093/jac/dkv045. Epub 2015 Feb 23. PMID: 25712315; PMCID: PMC4447890.





