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YM-244769 hydrochloride是一种口服有效的选择性Na+/Ca2+交换体（NCX）抑制剂。它优先抑制NCX3及NCX外向电流，能预防缺氧/复氧诱导的神经元损伤，并可增加小鼠尿量及电解质排泄。

[1] Yamashita K, Watanabe Y, Kita S, Iwamoto T, Kimura J. Inhibitory effect of YM-244769, a novel Na+/Ca2+ exchanger inhibitor on Na+/Ca2+ exchange current in guinea pig cardiac ventricular myocytes. Naunyn Schmiedebergs Arch Pharmacol. 2016 Nov;389(11):1205-1214. doi: 10.1007/s00210-016-1282-y. Epub 2016 Aug 1. PMID: 27480939.[2]Gotoh Y, Kita S, Fujii M, Tagashira H, Horie I, Arai Y, Uchida S, Iwamoto T. Genetic knockout and pharmacologic inhibition of NCX2 cause natriuresis and hypercalciuria. Biochem Biophys Res Commun. 2015 Jan 9;456(2):670-5. doi: 10.1016/j.bbrc.2014.12.016. Epub 2014 Dec 11. PMID: 25498502.