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Casticin（Vitexicarpin，蔓荆子黄素，紫花牡荆素）属于多甲氧基黄酮类化合物，能够抑制 STAT3 的活化，具有抗有丝分裂和抗炎活性。Casticin对乳腺癌、肺癌、宫颈癌、肝癌及胃癌等多种肿瘤细胞有较强的增殖抑制活性。Casticin可以介导多种药理活性，如抗氧化，抗病毒，心血管保护，抗肿瘤和抗炎等。

参考文献

[1] Guan-Ling Chou, Shu-Fen Peng, Ching‐Lung Liao, et al. Casticin impairs cell growth and induces cell apoptosis via cell cycle arrest in human oral cancer SCC‐4 cells. 2018, 33(2):127-141.

[2] Fan Li, Zhang Yi, Zhou Qiuhong, et al. Casticin inhibits breast cancer cell migration and invasion by down-regulation of PI3K/Akt signaling pathway. 2018, 38(6) 4(2): 1123-1127.

[3] MENG Fanmin. Apoptosis of human prostate cancer PC-3 cells induced by vine flavin and its effect on G2 /M phase arrest[D]. Dalian: Liaoning Normal University, 2013.

[4] Zhou L, et al. Casticin attenuates liver fibrosis and hepatic stellate cell activation by blocking TGF-β/Smad signaling pathway. Oncotarget. 2017 Apr 27;8(34):56267-56280.

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