Esmolol hydrochloride是一种超短效心脏选择性β1-肾上腺素能阻滞剂,通过激活NK1受体发挥抗心律失常作用,并能减轻复苏后心肌功能障碍。它还可通过抑制醛糖还原酶等机制改善糖尿病伤口愈合,适用于心律失常等心脏疾病及糖尿病足溃疡的研究。
|
英文别名 (English Synonym) |
Esmolol HCl |
|
中文名称 (Chinese Name) |
盐酸艾司洛尔 |
|
靶点 (Target) |
Adrenergic Receptor |
|
通路 (Pathway) |
GPCR/G protein |
|
CAS号 (CAS NO.) |
81161-17-3 |
|
分子式 (Formula) |
C16H25NO4·HCl |
|
分子量 (Molecular Weight) |
331.83 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Kulkarni SA, Deshpande SK, Rastogi A. Novel topical esmolol hydrochloride improves wound healing in diabetes by inhibiting aldose reductase, generation of advanced glycation end products, and facilitating the migration of fibroblasts. Front Endocrinol (Lausanne). 2022 Aug 23,13:926129. doi: 10.3389/fendo.2022.926129. PMID: 36082077, PMCID: PMC9446078.[2]Zhang Q, Li C. Combination of epinephrine with esmolol attenuates post-resuscitation myocardial dysfunction in a porcine model of cardiac arrest. PLoS One. 2013 Dec 18,8(12):e82677. doi: 10.1371/journal.pone.0082677. PMID: 24367539, PMCID: PMC3867387.
