Amikacin disulfate（BAY 41-6551 disulfate）是一种半合成氨基糖苷类抗生素,通过作用于细菌30S/50S核糖体亚基以抑制蛋白质合成,发挥杀菌作用。它对多数革兰氏阴性菌（含庆大霉素和妥布霉素抗性株）及部分诺卡氏菌、非结核分枝杆菌均高度有效。
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英文别名 (English Synonym) |
Amikacin disulfate |
|
中文名称 (Chinese Name) |
阿米卡星硫酸盐 |
|
靶点 (Target) |
Anti-infection |
|
通路 (Pathway) |
Microbiology/Virology |
|
CAS号 (CAS NO.) |
39831-55-5 |
|
分子式 (Formula) |
C22H43N5O13·2H2O4S |
|
分子量 (Molecular Weight) |
781.76 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于H2O |
-25~-15℃保存，有效期3年
[1] Edson RS, Terrell CL. The aminoglycosides. Mayo Clin Proc. 1999 May,74(5):519-28. doi: 10.4065/74.5.519. PMID: 10319086.[2]Kitcher SR, Kirkwood NK, Camci ED, Wu P, Gibson RM, Redila VA, Simon JA, Rubel EW, Raible DW, Richardson GP, Kros CJ. ORC-13661 protects sensory hair cells from aminoglycoside and cisplatin ototoxicity. JCI Insight. 2019 Aug 8,4(15):e126764. doi: 10.1172/jci.insight.126764. PMID: 31391343, PMCID: PMC6693895.
