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Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.

推荐稀释比 WB:1/500-1/1000;IP:1/20

Western blot analysis of Phospho-IRE1 (Ser724) in MCF-7, HL-60 lysates using Phospho-IRE1 (Ser724) antibody.

-25 ~ -15℃保存，收到货之后有效期1年，避免反复冻融。