叶下珠素（Phyllanthin）是一种具有口服活性的天然产物，通过抑制细胞活力、诱导凋亡以及阻碍迁移和侵袭发挥抗癌作用；其抗纤维化机制涉及ALK5/Smad2/3通路的抑制，此外还兼具抗炎和抗菌特性。
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2~8℃避光保存，有效期3年。
[1] Harikrishnan H, Jantan I, Haque MA, Kumolosasi E. Phyllanthin from Phyllanthus amarus inhibits LPS-induced proinflammatory responses in U937 macrophages via downregulation of NF-κB/MAPK/PI3K-Akt signaling pathways. Phytother Res. 2018 Dec;32(12):2510-2519. doi: 10.1002/ptr.6190. Epub 2018 Sep 20. PMID: 30238535.
[2]You Y, Zhu F, Li Z, Zhang L, Xie Y, Chinnathambi A, Alahmadi TA, Lu B. Phyllanthin prevents diethylnitrosamine (DEN) induced liver carcinogenesis in rats and induces apoptotic cell death in HepG2 cells. Biomed Pharmacother. 2021 May;137:111335. doi: 10.1016/j.biopha.2021.111335. Epub 2021 Feb 12. PMID: 33581648.
