Fenoprofen Calcium hydrate (LILLY-53858)是一种非甾体抗炎药(NSAID),通过抑制环氧合酶(COX)发挥作用。它还是黑皮质素受体(MCR)的正向变构调节剂(PAM),并能增强HEK293T细胞中的ERK1/2活化,具有抗关节炎活性,可用于类风湿性关节炎及骨关节炎的研究。
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英文别名 (English Synonym) |
Fenoprofen calcium hydrate |
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中文名称 (Chinese Name) |
非诺洛芬钙水合物 |
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靶点 (Target) |
|
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通路 (Pathway) |
Immunology/Inflammation |
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CAS号 (CAS NO.) |
71720-56-4 |
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分子式 (Formula) |
C30H30CaO8 |
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分子量 (Molecular Weight) |
558.63 |
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纯度 (Purity) |
≥98% |
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溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Yuan XC, Tao YX. Fenoprofen-An Old Drug Rediscovered as a Biased Allosteric Enhancer for Melanocortin Receptors. ACS Chem Neurosci. 2019 Mar 20,10(3):1066-1074. doi: 10.1021/acschemneuro.8b00347. Epub 2018 Oct 11. PMID: 30168706.[2]Montero-Melendez T, Forfar RA, Cook JM, Jerman JC, Taylor DL, Perretti M. Old drugs with new skills: fenoprofen as an allosteric enhancer at melanocortin receptor 3. Cell Mol Life Sci. 2017 Apr,74(7):1335-1345. doi: 10.1007/s00018-016-2419-3. Epub 2016 Nov 16. PMID: 27853832, PMCID: PMC5346439.
