Paroxetine HCl是一种高效的5-羟色胺再摄取抑制剂,同时可抑制GRK2活性（IC50=14 μM）,可用于抑郁症研究。
|
英文别名 (English Synonym) |
Paroxetine HCl |
|
中文名称 (Chinese Name) |
盐酸帕罗西汀 |
|
靶点 (Target) |
AChR |
|
通路 (Pathway) |
Neuroscience |
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CAS号 (CAS NO.) |
78246-49-8 |
|
分子式 (Formula) |
C19H20FNO3·HCl |
|
分子量 (Molecular Weight) |
365.83 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Wang Q, Wang L, Wu L, Zhang M, Hu S, Wang R, Han Y, Wu Y, Zhang L, Wang X, Sun W, Wei W. Paroxetine alleviates T lymphocyte activation and infiltration to joints of collagen-induced arthritis. Sci Rep. 2017 Mar 28,7:45364. doi: 10.1038/srep45364. PMID: 28349925, PMCID: PMC5368980.[2]Waldschmidt HV, Homan KT, Cato MC, Cruz-Rodríguez O, Cannavo A, Wilson MW, Song J, Cheung JY, Koch WJ, Tesmer JJ, Larsen SD. Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine. J Med Chem. 2017 Apr 13,60(7):3052-3069. doi: 10.1021/acs.jmedchem.7b00112. Epub 2017 Mar 29. Erratum in: J Med Chem. 2019 Jun 27,62(12):5920. doi: 10.1021/acs.jmedchem.9b00844. PMID: 28323425, PMCID: PMC5641445.
